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Expansion and Enrichment of Gamma-Delta γδ T Cells from Apheresed Human Product
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Docking Complete: A Step Further toward the Holy Grail of γδ T Cell Biology
Ningning Cai1, Shuai Han1, Yonghui Zhang1
1School of Pharmaceutical Sciences; Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, 100084 Beijing, China.
Immunity
|November 21, 2019
Abstract:
The direct ligands recognized by γδ T cell receptors (γδ TCRs) remain uncertain and controversial. In a study appearing in this issue, Willcox et al. use surface plasmon resonance and isothermal titration calorimetry to demonstrate that B7-like molecule BTNL3 makes physical contact with V4γ-bearing TCRs on γδ T cells.

