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Current Clinical Trials in the Treatment of Advanced Melanomas

Saro Sarkisian1, Suresh Nair1, Rohit Sharma2

  • 1Department of Hematology/Oncology, Lehigh Valley Cancer Institute, 1240 South Cedar Crest Boulevard, Allentown, PA 18103, USA.

The Surgical Clinics of North America
|November 23, 2019
PubMed

Insights

Recent advances in understanding melanoma pathogenesis have revolutionized metastatic melanoma treatment. Immunotherapy and targeted therapies, alongside landmark trials, have transformed patient outcomes, with ongoing trials promising further improvements.

Area of Science:

  • Oncology
  • Genetics
  • Immunology

Background:

  • Metastatic melanoma treatment has significantly evolved over the last decade.
  • Improved understanding of melanoma pathogenesis, including key pathways and mutations, has driven therapeutic advancements.

Purpose of the Study:

  • To review historical and landmark clinical trials that have reshaped advanced melanoma treatment paradigms.
  • To discuss ongoing clinical trials with potential to improve future patient outcomes.

Main Methods:

  • Review of historical clinical trial data.
  • Analysis of landmark studies in melanoma treatment.
  • Survey of current and upcoming clinical trials.

Main Results:

  • Immunotherapy marked the initial breakthrough in treatment.
  • Targeted therapies, initially as monotherapy, then in combination, further advanced care.
  • A significant shift in the treatment paradigm for advanced melanomas has occurred.

Conclusions:

  • The understanding of melanoma pathogenesis has led to revolutionary treatment strategies.
  • Past and present clinical trials have dramatically improved outcomes for patients with advanced melanoma.
  • Future clinical trials are expected to continue this positive trajectory.
Keywords:
Advanced melanomasClinical trialsImmunotherapyMelanomaTargeted therapy

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