Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

6.1K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
6.1K
Papillary Dermis01:11

Papillary Dermis

5.3K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.3K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

4.1K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.1K
Cells of the Epidermis01:24

Cells of the Epidermis

6.6K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
6.6K
Skin Cancer01:30

Skin Cancer

5.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.6K
Reticular Dermis01:15

Reticular Dermis

4.4K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to Barnawi et al., "Bullous pemphigoid in the era of immunotherapy: Implications for treatment algorithms".

Journal of the American Academy of Dermatology·2026
Same author

Pustular Dermatoses. Part II. Infectious, Genetic, and Transient Neonatal.

Journal of the American Academy of Dermatology·2026
Same author

Pustular Dermatoses. Part I. Inflammatory and Autoimmune.

Journal of the American Academy of Dermatology·2026
Same author

US expert opinions on the treatment of bullous pemphigoid based on guidelines from the European Academy of Dermatology and Venereology.

Journal of the American Academy of Dermatology·2026
Same author

Adaptation and Validation of the Fear of Blistering Disease Recurrence Inventory.

Dermatology (Basel, Switzerland)·2025
Same author

Brown patches and erosions with an erythematous base.

JAAD case reports·2025

Related Experiment Video

Updated: Jan 3, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

15.1K

A Niche for Plasma Cells: The Skin.

Selda Karaaslan1, Mary M Tomayko2

  • 1Department of Dermatology, Yale University, New Haven, Connecticut, USA.

The Journal of Investigative Dermatology
|November 23, 2019
PubMed
Summary

Healthy skin hosts antibody-secreting plasma cells and plasmablasts. Inflammation and immunization boost these cell populations, advancing understanding of skin immunity in health and disease.

More Related Videos

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
05:58

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

19.3K
In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

12.9K

Related Experiment Videos

Last Updated: Jan 3, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

15.1K
Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
05:58

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

19.3K
In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

12.9K

Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Antibodies are crucial for the skin immune barrier.
  • Antibodies targeting skin structures can cause disease.
  • The role of B cells and plasma cells in skin immunity requires further elucidation.

Purpose of the Study:

  • To investigate the presence and dynamics of antibody-secreting cells in healthy and inflamed skin.
  • To understand how inflammation and immunization affect the populations of skin-associated B cells and plasma cells.
  • To advance the comprehension of B and plasma cell functions within the skin's immune microenvironment.

Main Methods:

  • Analysis of skin biopsies.
  • Immunohistochemistry to identify specific cell populations.
  • Flow cytometry for quantitative analysis of B cells and plasma cells.

Main Results:

  • Healthy skin serves as a niche for antibody-secreting plasma cells and plasmablasts.
  • Inflammation and immunization lead to a significant increase in the numbers of these cells in the skin.
  • Demonstration of skin-associated B and plasma cells' active role in immune responses.

Conclusions:

  • Skin harbors a distinct population of antibody-secreting cells that contribute to its immune barrier function.
  • The cellularity of these populations is dynamically regulated by inflammatory and immunizing stimuli.
  • This study provides critical insights into the pathogenesis of skin diseases involving autoantibodies and enhances understanding of skin-associated B cell immunology.