Oral Modified Drug Release Solid Dosage Form with Special Reference to Design; An Overview

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems

Background:

• Oral drug delivery is the most common administration route, but conventional tablets/capsules cause fluctuating drug levels, leading to toxicity and reduced efficacy.
• Maintaining therapeutic drug concentrations is crucial for effective treatment, which is challenging with standard oral formulations due to unpredictable absorption and repetitive dosing needs.

Purpose of the Study:

• To review the fundamental principles of oral modified drug delivery systems.
• To discuss the design criteria and influencing factors for modified release dosage forms.

Main Methods:

• This is a review article, synthesizing existing knowledge on modified release oral drug delivery.
• Key concepts, advantages, and influencing factors of sustained, prolonged, modified, and extended release formulations are discussed.

Main Results:

• Modified release oral drug delivery systems are designed for controlled medication release over extended durations.
• These systems aim to maintain drug plasma concentrations within the therapeutic index, improving treatment outcomes.
• Selection criteria and factors affecting dosage and release patterns for these advanced formulations are outlined.

Conclusions:

• Oral modified drug delivery systems represent a significant advancement over conventional oral dosage forms.
• These systems enhance therapeutic efficacy, reduce toxicity, and improve patient compliance by providing controlled drug release.
• Understanding the design principles and influencing factors is essential for optimizing the performance of modified release formulations.