Polymeric ionic liquid immobilized onto paper as sorptive phase in microextraction.

Area of Science:

• Analytical Chemistry
• Materials Science

Background:

• Polymeric ionic liquids (PILs) offer tunable properties for separation science.
• Paper-based analytical devices are gaining traction for their low cost and portability.

Purpose of the Study:

• To develop a new planar sorptive phase based on polymeric ionic liquids immobilized on paper.
• To evaluate the performance of this new material for extracting non-steroidal anti-inflammatory drugs (NSAIDs) from urine samples.

Main Methods:

• Polymeric ionic liquid synthesis via the Radziszewski reaction in aqueous media.
• Immobilization of PILs onto paper using thermal curing.
• Extraction of NSAIDs from urine followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis.

Main Results:

• The developed paper sorbent exhibited hydrophobic and mixed-mode interaction capabilities.
• Method detection limits for NSAIDs ranged from 3.8 to 15.7 μg/L.
• Linear calibration models (R² > 0.9949) up to 1000 μg/L were achieved with good intra-day precision (1.1-13%) and accuracy (72-95% recovery).

Conclusions:

• The proposed polymeric ionic liquid-on-paper sorptive phase is a simple, effective, and sensitive tool for NSAID analysis in urine.
• The method's ease of synthesis and high sample throughput make it suitable for routine analysis.