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Polydopamine -aminoglycoside nanoconjugates: Synthesis, characterization, antimicrobial evaluation and
Indu Singh1, Ayushi Priyam2, Diksha Jha3
1Microbial Biotechnology Laboratory, CSIR-Institute of Genomics and Integrative Biology, Sukhdev Vihar, New Delhi, 110025, India; Department of Biomedical Sciences, Acharya Narendra Dev College, University of Delhi, Kalkaji, New Delhi, 110019, India.
Researchers developed novel polydopamine nanoparticles conjugated with aminoglycosides (AGs) for antimicrobial applications. The PDA-Kanamycin nanoconjugate showed potent activity against resistant bacteria with selective toxicity.
Area of Science:
- Nanotechnology
- Biomaterials Science
- Drug Delivery
Background:
- Nanoparticle and self-assembled nanomaterial-based therapeutics are rapidly advancing.
- Dopamine self-polymerizes into polydopamine (PDA), a versatile biopolymer for therapeutic development.
Purpose of the Study:
- To synthesize and characterize polydopamine-aminoglycoside (PDA-AG) nanoconjugates.
- To evaluate the antimicrobial potency and cytocompatibility of PDA-AG nanoconjugates.
Main Methods:
- Self-polymerization of dopamine to form PDA nanoparticles.
- Tethering aminoglycosides (Gentamicin, Kanamycin, Neomycin) to PDA nanoparticles.
- Physicochemical characterization and antimicrobial/cytotoxicity assays.
Main Results:
- PDA-AG nanoconjugates were successfully synthesized.
- PDA-Kanamycin (PDA-K) exhibited the highest antimicrobial activity against resistant bacterial strains.
- PDA-K showed selective toxicity, with low impact on HEK 293 cells and high toxicity on U87 cells.
Conclusions:
- PDA-AG nanoconjugates demonstrate significant potential as novel antimicrobial agents.
- PDA-Kanamycin nanoconjugates show promise for future therapeutic applications due to their efficacy and selective toxicity.
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