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Updated: Jan 3, 2026

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
Published on: November 17, 2017
Plasma Energy Skin Rejuvenation
1Holcomb - Kreithen Plastic Surgery and MedSpa, 1 South School Avenue, Suite 800, Sarasota, FL 34237, USA.
Cold atmospheric plasma (CAP) offers skin rejuvenation benefits. Helium gas CAP shows promise for treating facial wrinkles, potentially due to its unique energy deposition and comprehensive tissue treatment, leading to greater skin contraction.
Area of Science:
- Dermatology and Aesthetic Medicine
- Plasma Physics and Engineering
Background:
- Cold atmospheric plasma (CAP) has been utilized in skin rejuvenation for over a decade, with nitrogen plasma skin regeneration (PSR) being an early application.
- Helium gas CAP is established in surgical fields and is now emerging for cosmetic applications, specifically facial rhytidosis (wrinkling).
Purpose of the Study:
- To compare the efficacy and mechanisms of nitrogen and helium gas CAP in skin rejuvenation.
- To investigate the reasons behind observed differences in skin tissue interaction between nitrogen and helium CAP.
Main Methods:
- Comparative analysis of skin tissue interaction following treatment with nitrogen and helium gas CAP.
- Evaluation of plasma generation and energy deposition characteristics for each CAP type.
Main Results:
- Animal studies indicate that differences in plasma generation and energy deposition influence skin tissue interaction.
- Helium PSR demonstrated greater skin tissue contraction compared to other CAPs, potentially due to its unique bimodal energy deposition.
- Helium CAP provided a more complete full-field treatment of the tissue.
Conclusions:
- Helium gas CAP presents a viable and emerging tool for facial skin rejuvenation, particularly for rhytidosis.
- The superior tissue contraction observed with helium PSR is likely linked to its distinct energy deposition properties and comprehensive treatment area.
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