Related Experiment Video
Updated: Jan 1, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
Clinical Aspects of Aging Skin: Considerations for the Wound Care Practitioner
1Associate Clinical Professor of Geriatric Medicine and Palliative Care, Icahn School of Medicine at Mount Sinai, New York, New York.
General Purpose:
To provide information about changes associated with aging skin and the implications for wound care practitioners.
Target Audience:
This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.
Learning Objectives/Outcomes:
After participating in this educational activity, the participant should be better able to:1. Describe proposed biologic theories of aging and the biology of aging skin.2. Discuss the clinical consequences of aging skin and the implications for wound care practitioners.
Abstract:
Aging is a complex phenomenon manifested by macromolecular damage, adverse changes to the genome, blunted immunologic function, alterations in body composition, and decreased adaptation to stress. Understanding the changes that skin undergoes with age is essential for wound care practitioners. Accordingly, this article will introduce the reader to theories of aging, the biologic changes associated with aging skin, and clinical considerations for the wound care practitioner, including the concepts of skin failure, Skin Changes At Life's End, and frailty.
Related Concept Videos
The Effect of Aging on Tissues
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Clinical Applications of Epidermal Stem Cells
Renewal of Skin Epidermal Stem Cells

