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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

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Reduced bile acid excretion is an independent risk factor for stroke and mortality: A prospective follow-up study

Gideon Charach1, Eli Karniel1, Ilya Novikov1

  • 1Department of Internal Medicine B, Meir Medical Center, Kfar Saba, Israel; Affiliated with Sackler Medical School, Tel Aviv University, Tel Aviv, Israel.

Atherosclerosis
|December 24, 2019
PubMed

Insights

Lower bile acid excretion (BAE) is linked to increased stroke risk. This finding suggests BAE may be an independent risk factor for stroke, even after accounting for other potential causes.

Area of Science:

  • Cardiovascular Medicine
  • Gastroenterology
  • Metabolic Disorders

Background:

  • Hypercholesterolemia is a significant risk factor for atherosclerosis, a primary cause of cardiovascular diseases including stroke.
  • Bile acid excretion (BAE) plays a role in cholesterol metabolism and may influence cardiovascular health.

Purpose of the Study:

  • To investigate the association between bile acid excretion (BAE) and the incidence of stroke.
  • To determine if BAE is an independent risk factor for stroke.

Main Methods:

  • A retrospective, historical cohort follow-up study was conducted on patients admitted for chest pain and suspected coronary artery disease (CAD).
  • Bile acid excretion (BAE) was evaluated using a 24-hour stool collection and a continuous, non-absorbable marker.
  • Patients were followed from 1998 to 2018 for stroke incidence and mortality.

Main Results:

  • Mean BAE was significantly higher in survivors compared to non-survivors (p<0.001).
  • Total BAE was significantly higher in stroke-free patients than in those who developed stroke (p<0.001).
  • Patients with low BAE (<262.4 mg/24h) had a 75% stroke incidence, while none with high BAE (>622 mg/24h) developed stroke.

Conclusions:

  • Lower amounts of total bile acid, deoxycholic acid, and lithocholic acid excretion are associated with increased stroke risk.
  • Low BAE was identified as a significant risk factor for stroke, potentially independent of other confounders.
Abstract

Keywords:
AtherosclerosisBile acidsCholesterolLow density lipoproteinStroke

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