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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.5K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Biomaterials for stem cell engineering and biomanufacturing.

Yibo Xu1, Chuanxin Chen1, Peter B Hellwarth1

  • 1Davidson School of Chemical Engineering, Purdue University, West Lafayette, West Lafayette, IN, 47907, USA.

Bioactive Materials
|December 25, 2019
PubMed
Summary
This summary is machine-generated.

This study reviews stem cell types and biomaterials for regenerative medicine. It explores their combination for tissue repair and discusses future biofabrication technologies for therapeutic manufacturing.

Keywords:
BiofabricationBiomanufacturingBiomaterialRegenerative medicineStem cells

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Stem Cell Biology

Background:

  • Increasing tissue failures and diseases necessitate advanced therapeutic strategies.
  • Regenerative medicine offers a promising approach, focusing on stem cell-biomaterial interactions.
  • Tissue engineering aims to create tailored biomaterials for cell growth and differentiation.

Purpose of the Study:

  • To summarize properties of embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and adult stem cells.
  • To describe characteristics of natural and synthetic biomaterials.
  • To review stem cell-biomaterial applications in tissue repair and future biofabrication.

Main Methods:

  • Literature review of stem cell properties (ESCs, iPSCs, adult stem cells).
  • Analysis of natural and synthetic biomaterial characteristics.
  • Synthesis of research on stem cell-biomaterial combinations for tissue repair across various systems.
  • Exploration of stem cell-related biomanufacturing and biofabrication technologies.

Main Results:

  • Detailed properties of ESCs, iPSCs, and adult stem cells are presented.
  • Natural and synthetic biomaterials are characterized for their suitability in regenerative medicine.
  • Successful applications of stem cell-biomaterial constructs for nervous, cardiovascular, pancreatic, hematopoietic, and musculoskeletal tissue repair are reviewed.
  • Emerging biofabrication technologies offer pathways for large-scale therapeutic manufacturing.

Conclusions:

  • Stem cell-biomaterial therapy is a key strategy in regenerative medicine.
  • Understanding stem cell and biomaterial properties is crucial for effective tissue engineering.
  • Advancements in biofabrication are essential for translating stem cell-biomaterial therapies into clinical practice.