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Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Related Experiment Video

Updated: Jan 1, 2026

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases

Published on: October 6, 2023

Restoring Vision Using Stem Cells and Transplantation.

Elisa Cuevas¹, Paresh Parmar¹, Jane C Sowden²

¹Stem Cells and Regenerative Medicine Section, University College London Great Ormond Street Institute of Child Health, and NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK.

Advances in Experimental Medicine and Biology

|December 30, 2019

Summary

This summary is machine-generated.

Stem cell therapies offer hope for restoring vision in degenerative retinal diseases like retinitis pigmentosa. This review highlights progress and challenges in using stem cells for retinal repair and regeneration.

Keywords:

Age-related macular disease Cell therapy Cell transplantation In vitro photoreceptor cells In vitro retinal pigmented epithelium Retinal degeneration Retinal organoids Retinitis pigmentosa Stem cell therapy Translational research

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Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye

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Published on: November 25, 2012

Area of Science:

Ophthalmology
Regenerative Medicine
Stem Cell Biology

Background:

Degenerative retinal diseases pose significant challenges for vision restoration.
Current treatments are limited, creating a need for novel therapeutic approaches.
Stem cell-based therapies are emerging as a promising strategy.

Purpose of the Study:

To review recent advancements in stem cell-based transplantation for vision restoration.
To discuss the challenges hindering the clinical application of these therapies.
To cover both retinal pigmented epithelium (RPE) and photoreceptor replacement strategies.

Main Methods:

Literature review of recent studies on stem cell transplantation in retinal diseases.
Analysis of progress in RPE and photoreceptor replacement therapies.
Identification of key challenges in the field.

Main Results:

Significant progress has been made in developing stem cell-based approaches for retinal repair.
Both RPE and photoreceptor replacement strategies show potential for vision restoration.
Several challenges remain, including cell survival, integration, and immune response.

Conclusions:

Stem cell transplantation holds considerable promise for treating retinal dystrophies.
Overcoming current challenges is crucial for successful clinical translation.
Further research is needed to optimize these therapies for widespread use.