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Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
[ADAPTIVE CAPABILITIES OF THE CARDIOVASCULAR SYSTEM IN ADOLESCENTS WITH NON-INFLAMMATORY MYOCARDIAL PATHOLOGY, TAKING
T Holovko1, N Shevchenko2, L Bogmat3
11Kharkiv National University named after V.N. Karazin, Faculty of Medicine, Department of Pediatrics N2, Ukraine.
The Aim Of The Study:
to study the adaptive capabilities of the cardiovascular system in children with non-inflammatory myocardial pathologies, taking into account morphofunctional indicators of the right and left ventricles of the heart.
Materials And Methods:
62 patients with non-inflammatory myocardial pathology were examined, 30 of them with minor abnormalities of the heart, 32 with various rhythm disturbances. The average age of the subjects was 14.56 ± 0.24 years. The morphofunctional state of the myocardium was assessed by the results of ultrasound Doppler examination of the heart in the "M" and "B" modes. To study the tolerance to minimal physical activity and its effect on the state of the cardiovascular system in children, a six-minute walk test was performed. To assess the functional tension of the cardiovascular system before and after six-minute walk test, the following indices were calculated: Allgauer's index, endurance coefficient by the formula of A. Kwaas, Robinson index, coefficient of blood circulation efficiency. To assess the effect of the autonomic nervous system on the performance of the cardiovascular system, the Kerdo Vegetative Index was determined. At rest, the index of functional changes of the circulatory system, or adaptive potential was also determined. As a result of the study, it was noted that children with non-inflammatory heart diseases showed a decrease in systolic myocardial function of both ventricles. In patients with minor abnormalities of the heart, this is accompanied by the formation of dilatation of the left ventricular cavity and an increase in myocardial mass. As a result of the study, it was noted that in children with non-inflammatory heart diseases, a decrease in systolic myocardial function of both ventricles is noted. In patients with MARS, this is accompanied by myocardial remodeling with dilatation of the left ventricular cavity and an increase in myocardial mass. Subclinical decline in functionality is detected in samples with physical activity (six-minute walk test). At the same time, to assess the functional reserves of the circulatory system and the child's body as a whole, as well as its adaptive capabilities, it is advisable to use the Allgover, Robinson indices, endurance coefficient and efficiency of blood circulation.
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