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Genetic Variation

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...

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Related Experiment Video

Updated: Dec 31, 2025

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

[GENETIC ASPECTS OF RESISTANCE TO MALARIA (REVIEW)].

S Larina¹, T Sakharova¹, E Gorozhanina¹

¹Sechenov First Moscow State Medical University, Russia.

Georgian Medical News

|January 1, 2020

Summary

Malaria significantly impacts human genetics, driving the evolution of red blood cell disorders. Understanding these genetic changes is key to developing new malaria treatments and prevention strategies.

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Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites

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Area of Science:

Genetics
Infectious Diseases
Hematology

Background:

Malaria is a major global infectious disease affecting millions worldwide.
It acts as a strong selective pressure on the human genome, particularly in tropical regions.
This pressure has led to genetic adaptations and diseases like sickle cell anemia.

Purpose of the Study:

To explore the genetic underpinnings of malaria resistance.
To investigate the role of red blood cell surface antigen polymorphism in malaria parasite invasion.
To understand how genetic factors influence malaria pathogenesis and clinical presentation.

Main Methods:

Analysis of genetic polymorphism associated with malaria.
Study of red blood cell surface antigen structures and their role in Plasmodium invasion.
Review of genetic disorders linked to malaria resistance and pathogenesis.

Main Results:

Genetic factors significantly influence malaria resistance and disease severity.
Red blood cell surface antigen structure is critical for Plasmodium erythrocyte invasion.
Specific genetic disorders are linked to malaria's selective pressure.

Conclusions:

Understanding genetic changes in red blood cells offers insights into malaria pathogenesis.
Genetic polymorphism plays a crucial role in malaria resistance and clinical outcomes.
Further research into these genetic factors can lead to novel malaria treatment and prevention strategies.