Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Cholesterol: Significance and Regulation

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[PHARMACOGENETIC ASPECTS OF TREATMENT OF PATIENTS WITH CHRONIC HEART FAILURE (REVIEW)].

Georgian medical news·2020

Same author

[PECULIARITIES OF INTERACTION IN THE "PARASITE-HOST" SYSTEM IN HIV-INFECTED PATIENTS WITH TOXOPLASMOSIS: LITERATURE AND CLINICAL CASE REVIEW].

Georgian medical news·2020

Same author

[CLINICAL DIAGNOSTIC VALUE OF OXIDATIVE STRESS MARKERS IN PATIENTS WITH CHRONIC HEART FAILURE. OPPORTUNITIES OF THEIR PHARMACOLOGICAL CORRECTION BY ETOXIDOL].

Georgian medical news·2020

Same author

[GENETIC ASPECTS OF RESISTANCE TO MALARIA (REVIEW)].

Georgian medical news·2020

Same author

[SEVERE FORMS OF TROPICAL MALARIA: MOLECULAR GENETIC FEATURES OF THE COURSE OF THE INFECTION (REVIEW)].

Georgian medical news·2019

Same author

[THE SIGNIFICANCE OF THE SYSTEM APPROACH IN THE STUDY OF THE GENERAL ADAPTATION SYNDROME' REACTIONS].

Georgian medical news·2019

Search research articles

Related Experiment Video

Updated: Dec 25, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

[CLINICAL CASE: THE SIDE EFFECTS OF STATINS].

V Kukes¹, N Chebyshev¹, L Pavlova¹

¹Sechenov First Moscow State Medical University, Russia.

Georgian Medical News

|April 4, 2020

Summary

Statins may slow aging and reduce cardiovascular disease risk by increasing telomerase activity. However, this may also increase cancer risk by upregulating the hTERT gene, necessitating safety studies.

More Related Videos

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

Related Experiment Videos

Last Updated: Dec 25, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

Area of Science:

Biochemistry
Gerontology
Oncology

Background:

Recent clinical studies indicate statins influence telomerase activity.
Telomere shortening is associated with aging and cardiovascular disease.
Telomerase activation is linked to cellular aging and potential malignancy.

Purpose of the Study:

To investigate the dual role of statins in telomere maintenance and cancer risk.
To evaluate the impact of statins on telomerase activity and hTERT gene expression.
To establish safety criteria for telomerase activators.

Main Methods:

Analysis of clinical data on statin use and telomere length.
Molecular assays to measure telomerase activity.
Gene expression analysis for hTERT.

Main Results:

Statins were observed to increase telomerase activity, decelerating telomere shortening.
Increased telomerase activity correlates with elevated hTERT gene expression.
Potential link between statin-induced telomerase activation and malignancy risk identified.

Conclusions:

Statins may offer benefits in cardiovascular health and aging by modulating telomere dynamics.
The upregulation of hTERT by statins presents a potential risk for cancer development.
Further research is crucial to define safe usage guidelines for telomerase-activating therapies.