Related Experiment Video

Updated: Dec 31, 2025

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.1K

Relationship Between Cognitive Dysfunction and Systemic Metabolic Disorders in Elderly: Dementia Might be a

Y Komuro1, K Oyama2, L Hu1

  • 1Department of Electrical and Electronic Engineering, NEWCAT Research Institute, Koriyama, Japan.

Advances in Experimental Medicine and Biology
|January 2, 2020
PubMed

Insights

Deep learning identified links between cognitive decline in vascular cognitive impairment (VCI) and metabolic issues. Systemic metabolic disorders and cerebral circulatory disturbances contribute to VCI, impacting elderly dementia risk.

Area of Science:

  • Neurology
  • Geriatrics
  • Medical Imaging
  • Artificial Intelligence

Background:

  • Vascular cognitive impairment (VCI) is a significant factor in elderly dementia.
  • VCI encompasses a spectrum of cognitive disorders linked to vascular pathology.
  • Lifestyle diseases and cerebrovascular disorders are prevalent in VCI patients.

Purpose of the Study:

  • To investigate the relationship between cognitive dysfunction and systemic metabolic disorders using deep learning (DL).
  • To evaluate the utility of time-resolved near infrared spectroscopy (TNIRS) and blood examination data in predicting cognitive function in VCI patients.

Main Methods:

  • Studied 202 patients (mean age 73.4 years) with VCI, assessing cognitive function via Mini Mental State Examination (MMSE).
  • Collected general blood examination data (Complete Blood Count, Basic Metabolic Panel) and measured cerebral blood oxygenation in the prefrontal cortex (PFC) using TNIRS.
  • Employed deep neural networks to predict MMSE scores based on TNIRS and blood data independently, then compared predictions.

Main Results:

  • A significant positive correlation (r=0.6, p<0.01) was found between TNIRS parameters and blood examination data.
  • Deep learning models demonstrated the potential to predict cognitive function (MMSE scores) from both TNIRS and blood data.

Conclusions:

  • Cognitive dysfunction in VCI patients is likely influenced by a combination of systemic metabolic disorders (energy/oxygen metabolism) and cerebral circulatory disturbances.
  • Arteriosclerosis, stemming from lifestyle-related diseases, appears to be a key contributor to these circulatory issues in VCI.

Keywords:
ArteriosclerosisDeep learningDementiaTime-resolved near infrared spectroscopyVascular cognitive impairment

More Related Videos

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

2.0K
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.5K

Related Concept Videos

Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
460
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
185
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.5K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
151
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
530
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
705