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Related Concept Videos

Fatigue01:21

Fatigue

767
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
767
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
Bone Disorders01:29

Bone Disorders

5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Fatigue Strength of Concrete01:22

Fatigue Strength of Concrete

481
Fatigue, in the context of materials science and engineering, refers to the weakening or failure of a material caused by repeatedly applied loads, even if these loads are below the strength limit of the material. Fatigue strength in concrete is a critical property that influences its durability and longevity. Concrete can fail in two ways due to fatigue. Static fatigue or creep rupture occurs under a constant load or one that increases slowly. The other failure mode is due to cyclical or...
481
Flail Chest-I01:24

Flail Chest-I

530
Overview of Flail Chest
Flail chest is a severe and potentially life-threatening condition characterized by the fracture of three or more adjacent ribs in multiple places. It is most commonly caused by direct impacts and trauma, such as motor vehicle accidents or injuries from a steering wheel impact. It can also occur due to falls in elderly individuals with osteoporosis, or assaults involving sharp objects.
Pathophysiology
The pathophysiology of flail chest is complex, involving fractures of...
530
Aging01:26

Aging

530
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
530

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Updated: Dec 31, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

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Frailty: What Is It?

Marco Proietti1,2, Matteo Cesari3,4

  • 1Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. marco.proietti@unimi.it.

Advances in Experimental Medicine and Biology
|January 3, 2020
PubMed
Summary
This summary is machine-generated.

Population aging is increasing frailty, a condition of vulnerability in older adults. Understanding frailty is crucial for modern geriatric medicine and healthcare system adaptation.

Keywords:
AgeingElderlyFrailtyGeriatric assessment

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Area of Science:

  • Gerontology and Public Health
  • Geriatric Medicine
  • Sociology of Aging

Background:

  • Global population is aging, with a projected increase in older and very old individuals over the next 30 years.
  • This demographic shift is linked to a rising prevalence of frailty in society.
  • Frailty is defined as a clinical state of increased vulnerability to stressors, leading to adverse health outcomes.

Purpose of the Study:

  • To discuss the concept of frailty.
  • To analyze its impact on healthcare systems.
  • To explore controversies in frailty assessment and its role in managing older adults.

Main Methods:

  • Literature review and conceptual analysis of frailty.
  • Discussion of its implications for geriatric medicine.
  • Examination of assessment methodologies and clinical management strategies.

Main Results:

  • Frailty is a significant consequence of population aging.
  • It presents a challenge to current healthcare systems.
  • Standardized assessment and management approaches are needed.

Conclusions:

  • Adopting frailty as a central concept can modernize geriatric medicine.
  • Effective management of frailty is essential for the well-being of the aging population.
  • Further research into assessment and interventions is warranted.