Related Experiment Video
Updated: Dec 31, 2025
09:30
A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
Published on: February 21, 2015
18.9K
Stem Cells in Psychiatry.
Jolanta Kucharska-Mazur1, Mariusz Z Ratajczak2,3, Jerzy Samochowiec4
1Pomeranian University of Medicine, Szczecin, Poland. jola_kucharska@tlen.pl.
Advances in Experimental Medicine and Biology
|January 4, 2020
Summary
Stem cell research offers new insights into the biological basis of mental disorders like depression and schizophrenia. This chapter explores stem cell roles in psychiatric conditions and their potential for novel treatments.
Area of Science:
- Psychiatry
- Regenerative Medicine
- Neuroscience
Background:
- Mental disorders lack a clear biological foundation.
- Regenerative medicine offers novel approaches to understanding brain function.
- Stem cells are crucial in understanding disease mechanisms.
Purpose of the Study:
- To explore the role of stem cells in psychiatric disorders.
- To examine stem cell trafficking in peripheral blood for major depressive disorder, bipolar disorder, schizophrenia, anxiety disorder, and alcohol dependence.
- To review neurogenesis and induced pluripotent stem cells in mental disorder research.
Main Methods:
- Literature review of stem cell research in psychiatry.
- Analysis of stem cell trafficking factors in psychiatric conditions.
- Examination of neurogenesis and iPSCs in mental disorder etiopathogenesis.
Main Results:
- Stem cell research is advancing the understanding of mental disorder biology.
- Stem cell trafficking in peripheral blood shows relevance in psychiatric disorders.
- Adult neurogenesis and iPSCs provide new avenues for research.
Conclusions:
- Stem cell research holds significant promise for unraveling the biological underpinnings of mental disorders.
- Understanding stem cell mechanisms can lead to innovative therapeutic strategies for psychiatric conditions.
- Further research into neurogenesis and iPSCs is crucial for advancing psychiatric treatment.
Keywords:
Anxiety disorderBipolar disorderComplement cascadeDepressionSDF-1SchizophreniaSphingosine-1-phosphateStem cellSterile inflammationMore Related Videos
10:43Developing HiPSC Derived Serum Free Embryoid Bodies for the Interrogation of 3-D Stem Cell Cultures Using Physiologically Relevant Assays
Published on: July 20, 2017
9.2K
11:27Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
Published on: November 18, 2013
12.6K
Related Concept Videos
01:13Induced Pluripotent Stem Cells
27.2K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
27.2K
01:06Induced Pluripotent Stem Cells
5.2K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
5.2K
01:21EPS and iPS Cells in Disease Research
3.3K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.3K
01:22iPS Cell Differentiation
3.0K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K
01:17Stem Cell Culture
5.9K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.9K
00:58Embryonic Stem Cells
32.0K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.0K