Fabrication and Evaluation of Cyclic Olefin Copolymer Based Implantable Neural Electrode

The purpose of this paper is to establish fabrication method of cyclic olefin copolymer(COC)-based neural electrode.

The fabrication started with preparing COC pellets into COC films by compression molding. Metal layers were deposited on the COC film and attached to a silicon wafer. Laser ablation was used to cut the outer edges and mark alignment keys. The metal layers were patterned using standard photolithography procedures. Finally, the isolated electrodes were laminated. To ensure that the resulting electrode is safe and suitable for long-term implants, in vitro biocompatibility test, impedance evaluation, accelerated soak test, and repeated bend test were conducted.

Cytotoxicity test and elution test confirmed the biocompatibility in vitro. The basic performance was not hindered compared to other polymer-based electrodes, and the longevity of the electrode was validated by accelerated soak test. However, repeated bend test revealed that the material might not be suitable for applications where constant bending is required.

The COC-based neural electrode was successfully fabricated. The material showed several merits such as biocompatibility, thermoplasticity, low water absorption rate, and high transparency, but should be limited to applications where repeated bending is not required.

Electrical circuits in implantable prosthetic devices must be hermetically encapsulated for a long period of time. Material such as COC with extremely low water absorption rate could have a significant impact on the longevity of these devices.