Related Experiment Video
Updated: Dec 31, 2025

Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus MRSA Infection
Published on: September 1, 2023
Clinical evaluation of subcutaneous administration of cefepime
B Pilmis1, A Mizrahi2, G Petitjean3
1Équipe mobile de microbiologie clinique, groupe hospitalier Paris Saint-Joseph, 75014 Paris, France; EA4043 unité bactéries pathogènes et santé, Université Paris-Sud Paris-Saclay, Chatenay-Malabry, France.
Objectives:
Cefepime is a fourth-generation cephalosporin active against Pseudomonas aeruginosa and most Enterobacteriaceae. Intravenous (IV) administration is the standard route of prescription. However, subcutaneous administration (SC) may represent an interesting alternative. We aimed to evaluate SC administration of cefepime versus the IV route in geriatric patients.
Patients And Methods:
Multicenter retrospective analysis in patients treated with cefepime by SC route who underwent plasma concentration monitoring.
Results:
Twelve patients were included in the SC group and matched to 12 patients in the IV group. The median and mean Cmin levels were 29.05mg/L [14.2-48.2]; 33.4mg/L (±21.8) in the SC group and 31.9mg/L [26.5-51.7]; 39.6mg/L (±27) (P=NS) in the IV group. No local SC administration-related complications were reported. No relapse was observed over six months of follow up.
Conclusion:
Subcutaneous use of cefepime seems to have the same clinical and microbiological effectiveness as parenteral administration.
Related Concept Videos
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
Dosage Interval and Administration Route: Determination Methods
Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Urine Studies II: Urine Culture and Sensitivity Test

