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Updated: Dec 31, 2025

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JUUL and Combusted Cigarettes Comparably Impair Endothelial Function.

Poonam Rao1, Jiangtao Liu2, Matthew L Springer1,2,3

  • 1Division of Cardiology, University of California, San Francisco, San Francisco, California.

Tobacco Regulatory Science
|January 14, 2020
PubMed
Summary
This summary is machine-generated.

Exposure to JUUL, other e-cigarettes, and traditional cigarettes all similarly impair endothelial function in rats. This study highlights the comparable vascular risks of vaping and smoking.

Keywords:
JUULcigarettese-cigarettesendothelial functionflow-mediated dilation

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Area of Science:

  • Cardiovascular Research
  • Toxicology
  • Pulmonary Medicine

Background:

  • Electronic cigarettes (e-cigs), including JUUL, are marketed as less harmful alternatives to combustible cigarettes.
  • Claims suggest vaping offers health benefits over smoking, but comprehensive health effect data remain limited.
  • Endothelial dysfunction is an early indicator of cardiovascular disease.

Purpose of the Study:

  • To compare the impact of JUUL aerosol, earlier generation e-cig aerosol, and cigarette smoke on endothelial function.
  • To assess if JUUL and e-cig aerosol cause endothelial dysfunction comparable to traditional cigarette smoke.

Main Methods:

  • Rats were exposed to aerosol from JUUL, an e-cig tank system, or combustible cigarettes, alongside a clean air control group.
  • Endothelial function was measured using flow-mediated dilation (FMD) before and after exposure.
  • Serum nicotine levels were analyzed post-exposure.

Main Results:

  • Exposure to JUUL aerosol, e-cig aerosol, and cigarette smoke all significantly impaired FMD in rats.
  • The degree of endothelial function impairment was comparable across all exposure groups (34%-58%).
  • Serum nicotine concentrations were highest in the JUUL group, with lower, comparable levels in other groups.

Conclusions:

  • Aerosol from JUUL and earlier generation e-cigarettes significantly impairs endothelial function in rats.
  • The vascular impairment caused by vaping JUUL and e-cigs is comparable to that caused by smoking traditional cigarettes.