The General Pediatrician's Guide to Isolated Thrombocytopenia

Platelets are an essential component of the hemostatic pathway; therefore, it is important to identify and diagnose patients with low platelet counts. This can be challenging, however, because thrombocytopenia can be relatively common and the differential diagnosis can be broad. Furthermore, because platelets can be affected both in form and function in a variety of medical conditions, platelet abnormalities can be the principal driver in some disorders but only a consequence in others. Critical factors in identifying the etiology of the thrombocytopenia include the severity and acuity of the patient's initial presentation along with the history, physical examination, and laboratory findings, all of which can provide important clues. The accurate diagnosis of thrombocytopenia is crucial for determining the appropriate management. This review highlights the key diagnostic considerations and recommended treatment when isolated thrombocytopenia is encountered in clinical practice. [Pediatr Ann. 2020;49(1):e27-e35.].