Software development for hepatopulmonary shunt estimation by gamma camera method in transarterial radioembolization

Area of Science:

• Radiology
• Nuclear Medicine
• Oncology

Background:

• Trans-arterial radioembolization (TARE) is a key treatment for unresectable liver cancers.
• Lung toxicity is a major limitation in TARE, necessitating accurate pre-treatment assessments.
• Hepatopulmonary shunt (HPS) quantification is vital for predicting and mitigating lung radiation dose.

Purpose of the Study:

• To develop and validate novel software for precise hepatopulmonary shunt (HPS) calculation.
• To enhance the accuracy of HPS estimation for trans-arterial radioembolization (TARE) planning.
• To ensure software compatibility across different GE XELERIS workstation versions.

Main Methods:

• Development of specialized HPS software integrated with GE XELERIS workstations.
• Utilizing ^99mTc macro aggregated albumin for shunt fraction estimation via gamma camera imaging.
• Testing the software's performance and accuracy on multiple XELERIS workstation versions.

Main Results:

• The developed HPS software provides accurate calculations for hepatopulmonary shunt fractions.
• The software demonstrated consistent performance and reliability across various GE XELERIS workstation versions.
• This tool facilitates improved pre-treatment assessment for TARE procedures.

Conclusions:

• The new HPS software offers a reliable method for accurate hepatopulmonary shunt quantification.
• Software validation across XELERIS versions ensures its broad applicability in clinical settings.
• Accurate HPS calculation using this software can optimize TARE treatment planning and patient safety.