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Updated: Dec 30, 2025

09:06
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
Published on: October 7, 2025
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A functionalized dumbbell probe-based cascading exponential amplification DNA machine enables amplified probing of
Jie Wang1, Shuhui Li, Jianguo Xu
1Cancer Metastasis Alert and Prevention Center, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention, College of Chemistry, Fuzhou University, Fuzhou 350002, China.
Abstract:
A functionalized dumbbell probe (FDP) based amplification method, termed as a cascading exponential amplification DNA machine (CEA-DNA machine), has been developed to autonomously accumulate single G-quadruplexes (SGQs) and twin-G-quadruplexes (TGQs) for robust fluorescence signal-on probing of miRNA-21.

