Related Experiment Video

Updated: Dec 30, 2025

Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells
07:19

Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells

Published on: September 28, 2011

36.7K

miR-TV: an interactive microRNA Target Viewer for microRNA and target gene expression interrogation for human cancer

Chao-Yu Pan1,2, Wen-Chang Lin1,2

  • 1Institute of Biomedical Informatics, National Yang-Ming University, Taipei 112, Taiwan.

Database : the Journal of Biological Databases and Curation
|January 18, 2020
PubMed

Insights

Researchers developed the miRNA Target Viewer (miR-TV), a web tool integrating microRNA (miRNA) and mRNA expression, clinical data, and survival information for cancer research. This bioinformatics tool aids in exploring miRNA expression and target genes in disease progression.

Area of Science:

  • Bioinformatics
  • Genomics
  • Cancer Research

Background:

  • MicroRNAs (miRNAs) are crucial regulators of gene expression in cellular processes.
  • Altered miRNA and gene expression levels are linked to cancer progression.
  • Survival analysis is vital for assessing cellular processes in cancer.

Purpose of the Study:

  • To develop a web tool, miRNA Target Viewer (miR-TV), for analyzing miRNA expression and target genes in cancer.
  • To integrate diverse datasets including miRNA/mRNA expression, clinical data, and survival information.
  • To provide a user-friendly interface for biomedical researchers to explore complex biological data.

Main Methods:

  • Integrated 5p-arm and 3p-arm miRNA expression profiles, mRNA target gene expression, and clinical data.
  • Utilized data from The Cancer Genome Atlas (TCGA) for miRNA-seq, mRNA-seq, and clinical information.
  • Incorporated miRNA target gene predictions from miRDB, TargetScan, and miRanda.
  • Implemented data visualization using the D3 javascript toolkit for an interactive interface.

Main Results:

  • Established the miRNA Target Viewer (miR-TV) web tool.
  • miR-TV integrates multi-omics data (miRNA, mRNA, clinical) with survival information.
  • The tool offers an interactive and user-friendly platform for data exploration.

Conclusions:

  • miR-TV facilitates the interrogation of miRNA expression and potential target genes in cancer.
  • The bioinformatics tool aids researchers in extracting insights from large-scale biological datasets.
  • miR-TV supports research into the role of miRNAs in cancer progression and patient survival.

More Related Videos

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.8K
Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

17.9K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.8K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.3K