MXene Titanium Carbide-based Biosensor: Strong Dependence of Exfoliation Method on Performance.

Area of Science:

• Materials Science
• Nanotechnology
• Electrochemistry

Background:

• MXenes are a novel class of 2D materials derived from MAX phases.
• They possess unique electrochemical properties like high surface area and conductivity.
• These properties make MXenes promising for sensing and energy applications.

Purpose of the Study:

• To develop a second-generation electrochemical glucose biosensor using MXene as a transducer platform.
• To evaluate the performance of pristine MXene (Ti3C2) in glucose detection.

Main Methods:

• Synthesis of Ti3C2 MXene via selective etching of MAX phases using HF and delamination with TBAOH.
• Fabrication of an electrochemical biosensor incorporating Ti3C2 MXene.
• Chronoamperometric analysis for glucose detection.

Main Results:

• The MXene-based biosensor exhibited high selectivity and excellent electrocatalytic activity for glucose.
• A wide linear detection range of 50–27750 μM was achieved.
• A low limit of detection of 23.0 μM was determined.

Conclusions:

• Pristine MXenes show significant potential for biosensing applications.
• This study paves the way for developing advanced electrochemical biosensors for biomedical and food analysis.