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Related Experiment Video

Updated: Dec 29, 2025

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
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3D-Printed Gastric Resident Electronics.

Yong Lin Kong1, Xingyu Zou1,2,3,4,5,6, Caitlin A McCandler1,2,3,4,5,6

  • 1Department of Mechanical Engineering University of Utah Salt Lake City, UT 84112, USA.

Advanced Materials Technologies
|February 4, 2020
PubMed
Summary
This summary is machine-generated.

A new gastric resident electronic (GRE) system allows orally delivered devices to stay in the stomach for up to 36 days. This innovation enables 15 days of wireless communication for advanced diagnostics and therapies.

Keywords:
3D printingbiomedical devicesgastric resident devicesgastric resident electronicsingestible electronics

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Area of Science:

  • Biomedical Engineering
  • Gastroenterology
  • Implantable Devices

Background:

  • Long-term biomedical electronics require invasive implantation and specialized communication hardware.
  • Current ingestible electronics have limited residence times and communication capabilities.

Purpose of the Study:

  • To develop an orally delivered electronic system for long-term gastric residence and wireless communication.
  • To overcome the limitations of invasive procedures and passive ingestible devices.

Main Methods:

  • Development of a multimaterial prototyping approach for a gastric resident electronic (GRE) system.
  • Leveraging the gastric environment for device residence and Bluetooth communication.
  • In vivo studies in a porcine model to evaluate device longevity and communication.

Main Results:

  • The GRE system achieved residence in the gastric environment for up to 36 days.
  • Sustained wireless electronics communication for approximately 15 days was demonstrated.
  • Successful interfacing with portable consumer electronics via Bluetooth.

Conclusions:

  • The GRE system offers a novel, non-invasive platform for long-term in-body electronic applications.
  • Synergistic integration of residence structure, drug release, and wireless electronics enables future remote diagnostics and automated therapies.