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Updated: Dec 29, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

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Published on: January 21, 2020

CORRELATION BETWEEN CONNECTIVE TISSUE METABOLISM AND THYROID DYSFUNCTION IN RATS WITH PERIODONTITIS.

V Shcherba¹, V Machogan¹, V Luchynskyi¹

¹1I. Horbachevsky Ternopil National Medical University, Ukraine.

Georgian Medical News

|February 4, 2020

Summary

Thyroid dysfunction significantly impacts connective tissue metabolism during periodontitis development in rats. Hypothyroidism showed more correlations between thyroid hormones and connective tissue markers than hyperthyroidism.

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Area of Science:

Endocrinology
Periodontology
Biochemistry

Background:

Periodontitis is a complex inflammatory disease affecting tooth-supporting structures.
Thyroid hormones play a crucial role in regulating metabolism, including connective tissue.
The interplay between thyroid dysfunction and periodontitis pathogenesis requires further elucidation.

Purpose of the Study:

To investigate the mechanisms of periodontitis development in rats with experimentally induced thyroid dysfunction.
To comparatively analyze correlations between connective tissue metabolism indices and thyroid hormone levels.
To understand the regulatory influence of the thyroid gland on connective tissue metabolism during periodontitis.

Main Methods:

Experimental periodontitis was induced in male rats with induced hyperthyroidism and hypothyroidism.
Serum concentrations of thyroid stimulating hormone, free thyroxine, and free triiodothyronine were measured using ELISA.
Collagenolytic activity, glycosaminoglycans, free hydroxyproline, and fucose levels were determined spectrophotometrically.
Pearson correlation analysis was employed to assess interrelationships between variables.

Main Results:

Distinct interconnections were observed between connective tissue metabolism indices and thyroid hormone concentrations in rats with periodontitis and thyroid dysfunction.
Thyroid dysfunction significantly alters connective tissue metabolism during periodontitis.
A greater number of correlations were found in hypothyroid rats compared to hyperthyroid rats, suggesting a more pronounced impact of hypothyroidism.

Conclusions:

The thyroid gland exerts a regulatory influence on connective tissue metabolism in the context of experimental periodontitis.
Thyroid dysfunction, particularly hypothyroidism, significantly modulates the biochemical processes involved in periodontitis.
Findings highlight the importance of considering thyroid status in the management and understanding of periodontitis.