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Updated: Dec 29, 2025
Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
Published on: March 25, 2019
Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission
Ji-An Chen1, Hongming Pan, Zhijun Wang
1Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201301, China. xfgu@fudan.edu.cn.
Abstract:
We herein develop two β-galactosidase (β-Gal) activatable NIR fluorescent probes for visualizing ovarian cancers. Particularly, probe BOD-M-βGal produced NIR-II emission light at 900-1300 nm upon β-Gal activation. By using our activatable and target specific NIR-II probe for deep-tissue imaging of β-Gal overexpressed ovarian cancer cells, rapid and accurate imaging of ovarian tumors in nude mice was achieved.
