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Effects of Exercise on the Tumour Microenvironment.
1Mackenzie Cancer Research Group, Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand.
Advances in Experimental Medicine and Biology
|February 8, 2020
Summary
Exercise may improve cancer patient survival by influencing the tumor microenvironment (TME). Understanding exercise
Area of Science:
- Exercise oncology
- Tumor microenvironment (TME) research
- Cancer patient survival mechanisms
Background:
- Epidemiological studies link exercise to improved cancer survival.
- The precise mechanisms and conditions for exercise's benefit remain unclear.
- Tumor microenvironment (TME) interactions are crucial for tumor growth and aggression.
Purpose of the Study:
- To explore how exercise influences the tumor microenvironment (TME).
- To investigate the role of exercise capacity and adaptability in cancer treatment.
- To identify future research directions in exercise oncology.
Main Methods:
- Review of current literature on exercise, TME, and cancer.
- Discussion of physiological effects of exercise on the TME.
- Analysis of factors like tumor perfusion, hypoxia, and immunity.
Main Results:
- Exercise impacts TME components including perfusion, vascularity, hypoxia, and immunity.
- Myokines and circulating factors play a role in mediating exercise's effects.
- Exercise capacity and adaptability may influence tumor responsiveness.
Conclusions:
- Exercise's impact on the TME is a key area for understanding its survival benefits in cancer patients.
- Further research is needed to elucidate the complex interplay between exercise, the TME, and cancer outcomes.
- Personalized exercise interventions may be crucial for optimizing benefits.
Keywords:
Anti-tumour immunityCancerExerciseExercise adaptationExercise capacityHypoxiaImmunologyMetastasisMyokinesPhysical activityPhysiologyPreclinicalTumour microenvironmentTumour perfusionVascularityMore Related Videos
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