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Updated: Dec 29, 2025

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
Tumor Microenvironment Conditioning by Abortive Lytic Replication of Oncogenic γ-Herpesviruses
1Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland. christian.muenz@uzh.ch.
Abstract:
Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) constitute the human γ-herpesviruses and two of the seven human tumor viruses. In addition to their viral oncogenes that primarily belong to the latent infection programs of these viruses, they encode proteins that condition the microenvironment. Many of these are early lytic gene products and are only expressed in a subset of infected cells of the tumor mass. In this chapter I will describe their function and the evidence that targeting them in addition to the latent oncogenes could be beneficial for the treatment of EBV- and KSHV-associated malignancies.
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