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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The Intestinal Tumour Microenvironment.

J K H Leman1, L Munoz-Erazo1,2, R A Kemp3

  • 1Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.

Advances in Experimental Medicine and Biology
|February 8, 2020
PubMed
Summary
This summary is machine-generated.

The complex intestinal tumour microenvironment (TME) involves immune cells, fibroblasts, and microbes. Their interactions critically influence colorectal cancer progression and treatment response.

Keywords:
AngiogenesisColorectal cancerFibroblastImmune cellIntestinesMacrophageMicrobiotaMicrosatellite instabilityNatural killer cellNeutrophilT cellTumour

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Area of Science:

  • Oncology
  • Immunology
  • Microbiology

Background:

  • The intestinal tumour microenvironment (TME) is a complex ecosystem.
  • It includes stromal cells, tumor cells, immune cells, fibroblasts, and microorganisms.
  • Factors like tumor location and genetics shape the TME.

Purpose of the Study:

  • To explore the dynamic interplay within the intestinal TME.
  • To understand how the TME influences tumor development and progression.
  • To focus on immune cells, fibroblasts, and the gut microbiota in colorectal cancer.

Main Methods:

  • Literature review and synthesis of current research on TME.
  • Analysis of cellular interactions within the tumor microenvironment.
  • Focus on the role of immune cells and microbiota in colorectal cancer.

Main Results:

  • Immune cells within the TME can either inhibit or promote tumor growth.
  • The plasticity of immune cells is significantly influenced by the TME.
  • Interactions between immune cells and the gut microbiome are key drivers of tumor progression or regression.

Conclusions:

  • The TME is a critical determinant of colorectal cancer outcomes.
  • Targeting immune cells and the gut microbiota holds therapeutic potential.
  • Understanding TME dynamics is essential for improving cancer treatment strategies.