Related Experiment Video
Updated: Dec 29, 2025
10:21
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
681
S1P Signaling in the Tumor Microenvironment.
1James Graham Brown Cancer Center, Division of Medical Oncology & Hematology, Department of Medicine, University of Louisville, Louisville, KY, USA. Gabriela.Schneider@louisville.edu.
Advances in Experimental Medicine and Biology
|February 8, 2020
Summary
Sphingosine-1-phosphate (S1P) is a key signaling molecule in the tumor microenvironment, promoting cancer growth and immune evasion. Targeting S1P signaling presents a promising therapeutic strategy for developing novel anticancer treatments.
Area of Science:
- Oncology
- Immunology
- Cell Biology
Background:
- Sphingosine-1-phosphate (S1P) is a lipid signaling molecule regulating cellular functions within the tumor microenvironment (TME).
- S1P participates in crucial cell-cell communication, influencing various aspects of cancer progression.
Purpose of the Study:
- To elucidate the multifaceted roles of S1P in the TME.
- To highlight S1P as a potential therapeutic target in cancer treatment.
Main Methods:
- Literature review and analysis of S1P's known signaling pathways.
- Examination of S1P's influence on tumor growth, angiogenesis, metastasis, and immune response.
Main Results:
- S1P signaling promotes tumor growth, angiogenesis, chemoresistance, and metastasis.
- S1P modulates anticancer immune responses and inflammation within the TME.
- Cancer cells release S1P, altering TME component behavior to favor tumor progression.
Conclusions:
- S1P is a critical regulator of the tumor microenvironment and cancer progression.
- Targeting S1P signaling pathways offers a promising therapeutic avenue for cancer treatment.
- Ongoing development of S1P-targeting therapies shows potential for clinical application.
Keywords:
Cancer metastasisCell motilityChemotaxisHypoxia-inducible factor 1α (HIF1α)ImmunomodulationInflammationMacrophage polarizationNuclear factor-κB (NF-κB)Sphingosine kinase (SphK)Sphingosine-1 phosphate (S1P)Sphingosine-1 phosphate receptors (S1PR)TAM/M2 macrophagesTumor angiogenesisTumor growthTumor microenvironment
Related Concept Videos
02:17The Tumor Microenvironment
7.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.5K
01:19Interactions Between Signaling Pathways
7.1K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.1K
03:03mTOR Signaling and Cancer Progression
4.5K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.5K
02:38Mitogens and the Cell Cycle
7.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.6K
01:20The JAK-STAT Signaling Pathway
11.6K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
11.6K
01:17Intracellular Signaling Affects Focal Adhesions
3.4K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
3.4K