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Cytotoxic CD8+ Lymphocytes in the Tumor Microenvironment

Kota Iwahori1,2

  • 1Department of Clinical Research in Tumor Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan. iwahori@climm.med.osaka-u.ac.jp.

Advances in Experimental Medicine and Biology
|February 10, 2020
PubMed
Summary

Understanding CD8+ T cells in the tumor microenvironment is key for effective cancer immunotherapy. New technologies analyze T cell activity to improve treatments like CAR T cells and immune checkpoint inhibitors.

Keywords:
Bispecific T-cell engagerCD8+ T cellsCTLA-4Cytotoxic T cellsImmune checkpoint inhibitorNeoantigenPD-1PD-L1T-cell cytotoxicityT-cell exhaustionT-cell metabolismT-cell receptorTumor microenvironmentTumor mutation burdenTumor-specific antigen

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