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CCL4 Signaling in the Tumor Microenvironment.
Naofumi Mukaida1, So-Ichiro Sasaki2, Tomohisa Baba2
1Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan. mukaida@staff.kanazawa-u.ac.jp.
Advances in Experimental Medicine and Biology
|February 16, 2020
Summary
Chemokine CCL4 (macrophage inflammatory protein-1β) has dual roles in cancer, potentially promoting or inhibiting tumor growth. Further research is needed to evaluate CCR5 antagonists for cancer therapy.
Area of Science:
- Immunology
- Oncology
- Cell Biology
Background:
- CCL4, also known as macrophage inflammatory protein (MIP)-1β, is a CC chemokine that interacts with the CCR5 receptor.
- CCL4, alongside CCL3 and CCL5, influences various immune and non-immune cells within the tumor microenvironment.
Purpose of the Study:
- To investigate the multifaceted role of CCL4 in tumor development and immune response.
- To assess the potential of CCR5 antagonists as a cancer treatment strategy.
Main Methods:
- Analysis of existing evidence on CCL4's interactions with immune cells (T cells, macrophages) and stromal cells (fibroblasts, endothelial cells).
- Evaluation of CCL4's effects on tumor progression and anti-tumor immunity.
Main Results:
- CCL4 can promote tumor progression by recruiting regulatory T cells and pro-tumor macrophages.
- CCL4 also facilitates pro-tumorigenic functions of fibroblasts and endothelial cells.
- Conversely, CCL4 can enhance anti-tumor immunity by recruiting cytolytic lymphocytes and phagocytic macrophages.
Conclusions:
- The dual role of CCL4 in cancer necessitates a detailed analysis of its functions in the tumor microenvironment.
- The clinical application of CCR5 antagonists requires further investigation due to CCL4's complex effects.
Keywords:
ArrestinCCR5ChemokineChemotaxisCytolytic lymphocyteEndothelial cellFibroblastHuman immunodeficiency virusMacrophageMacrophage inflammatory proteinMetastasisMyeloid suppressor cellsNeutrophilsRegulatory T cellTrimeric G proteinMore Related Videos
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