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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Combined IMIG and Immune Ig Attenuate Allergic Responses in Beagle Dogs.

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Combined IMIG and immune Ig attenuates inflammatory colitis in mice.

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Mechanism(s) of prolonged attenuation of allergic responses after modulation of idiotypic regulatory network.

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Related Experiment Video

Updated: Dec 28, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

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IL-17 Signaling in the Tumor Microenvironment.

R M Gorczynski1

  • 1Department of Surgery & Immunology, University of Toronto, Toronto, ON, Canada. reg.gorczynski@utoronto.ca.

Advances in Experimental Medicine and Biology
|February 16, 2020
PubMed
Summary

Interleukin 17 (IL-17) and its receptor (IL-17R) play a complex role in the tumor microenvironment, influencing cancer growth and metastasis. Understanding these interactions offers potential new therapeutic strategies.

Keywords:
CancerCheckpoint blockadeChronic lymphocytic leukemia (CLL)CytokinesExtracellular signalingIL-17 isoformsIL-6Il-17R isoformsImmunoregulationImmunotherapyInflammationRegulatory T cells (Tregs)Tumor growth/survivalTumor metastasis/invasionTumor microenvironment (TME)

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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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Related Experiment Videos

Last Updated: Dec 28, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • Inflammation's dual role in tumor growth: promoting or inhibiting cancer progression.
  • The tumor microenvironment (TME) is shaped by extracellular signals from various cells.
  • Focus on the pro-inflammatory cytokine Interleukin 17 (IL-17) and its producing cells (Th17, non-T cells) within the TME.

Purpose of the Study:

  • To review the current understanding of IL-17/IL-17R signaling in the tumor microenvironment.
  • To explore the impact of IL-17/IL-17R on tumor growth and metastasis.
  • To highlight potential clinical applications of this knowledge.

Main Methods:

  • Literature review and synthesis of existing research on IL-17 and IL-17R in cancer.
  • Analysis of the IL-17 cytokine family and its receptor variants (IL-17RA-RE).
  • Discussion of cellular sources and targets of IL-17 signaling within the TME.

Main Results:

  • IL-17 family members (IL-17A-F) signal through IL-17 receptors (IL-17RA-RE).
  • IL-17/IL-17R interactions are implicated in modulating tumor growth and metastatic potential.
  • These interactions are influenced by diverse cell types within the TME.

Conclusions:

  • IL-17/IL-17R signaling is a critical component of the tumor microenvironment.
  • Targeting IL-17 pathways may offer novel therapeutic avenues for cancer treatment.
  • Further research is needed to fully elucidate and exploit these mechanisms in clinical settings.