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Fluorescence-based Measurement of Store-operated Calcium Entry in Live Cells: from Cultured Cancer Cell to Skeletal Muscle Fiber
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Tau Secretion.

Zhi Ruan1, Tsuneya Ikezu2

  • 1Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA. zhiruan@bu.edu.

Advances in Experimental Medicine and Biology
|February 26, 2020
PubMed
Summary
This summary is machine-generated.

Extracellular Tau protein actively spreads between cells, contributing to neurodegenerative tauopathies like Alzheimer's disease. Understanding Tau secretion mechanisms offers new therapeutic targets to halt disease progression.

Keywords:
Alzheimer’s diseaseExosomesMicrovesiclesTauopathiesTunneling nanotubes

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Pathological Tau protein propagation is central to tauopathies, including Alzheimer's disease.
  • Extracellular Tau plays a critical role in disease progression, despite its primary intracellular function.
  • Cell-to-cell transmission of Tau occurs via active secretion and uptake.

Purpose of the Study:

  • To review recent advances in understanding Tau secretion mechanisms.
  • To discuss the role of these mechanisms in Tau pathology development.
  • To highlight extracellular Tau as a potential therapeutic target.

Main Methods:

  • Review of current scientific literature on Tau secretion pathways.
  • Analysis of proposed exo-synaptic spreading mechanisms (exosomes, microvesicles, TNTs).
  • Discussion of experimental evidence supporting Tau propagation routes.

Main Results:

  • Tau can be actively secreted and taken up by adjacent cells.
  • Exo-synaptic pathways like exosomes, microvesicles, and tunneling nanotubes facilitate Tau spread.
  • Tau propagation involves both trans-synaptic and exo-synaptic routes.

Conclusions:

  • Extracellular Tau secretion is a key factor in tauopathy progression.
  • Targeting Tau secretion mechanisms presents a promising therapeutic strategy.
  • Further research into Tau secretion pathways is crucial for developing effective treatments.