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Olfactory and Neuropsychological Functioning in Olfactory Reference Syndrome.

Channing Sofko1, Geoffrey Tremont2, Jing Ee Tan3

  • 1Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI; Department of Psychiatry, Rhode Island Hospital, Providence, RI; Department of Psychiatry, The Miriam Hospital, Providence, RI; Division of Mental Health and Behavioral Sciences, Bay Pines Veterans Affairs Health Care System, Bay Pines, Florida.

Psychosomatics
|February 29, 2020
PubMed
Summary
This summary is machine-generated.

Olfactory reference syndrome (ORS) may involve cognitive and olfactory deficits. Further research is needed to understand this understudied psychiatric disorder.

Keywords:
neuropsychologyobsessive-compulsive and related disordersolfactionolfactory reference disorderolfactory reference syndrome

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Psychology

Background:

  • Olfactory reference syndrome (ORS) is a psychiatric disorder characterized by preoccupation with emitting an offensive body odor.
  • ORS is underrecognized and understudied, with limited empirical evidence on its features and etiology.
  • ORS is newly recognized in the International Classification of Diseases (11th Edition).

Purpose of the Study:

  • To investigate neuropsychological and olfactory functioning in individuals with ORS.
  • To determine if central nervous system or sensory dysfunction is associated with ORS.
  • To explore potential underlying mechanisms of ORS.

Main Methods:

  • Preliminary investigation involving 9 consecutive participants with ORS.
  • Participants completed structured clinical interviews.
  • Neuropsychological and olfaction evaluations were performed.

Main Results:

  • A proportion of individuals with ORS showed deficits in cognitive functioning, including processing speed and executive function.
  • Recognition memory bias for ORS-related words was observed.
  • Deficits in olfaction (odor detection and discrimination) and emotional processing were noted.

Conclusions:

  • Preliminary findings suggest cognitive, olfaction, and emotional processing deficits in ORS.
  • Further neuropsychological and olfaction studies are necessary.
  • These studies will help characterize this patient group and address study limitations.