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Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres
Published on: November 8, 2014
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Tumor budding in invasive breast cancer - An indispensable budding touchstone
B N Kumarguru1, Anikode S Ramaswamy1, Shahanuma Shaik2
1Department of Pathology, PES Institute of Medical Sciences and Research, Kuppam, Chittoor, Andhra Pradesh, India.
Indian Journal of Pathology & Microbiology
|February 29, 2020
Summary
High tumor budding in invasive breast cancer is linked to aggressive disease. This study found significant associations between high tumor budding and adverse histopathological and clinical factors.
Area of Science:
- Oncology
- Pathology
Background:
- Tumor budding, the detachment of tumor cells at the invasive front, is associated with aggressive cancer.
- Its significance is primarily studied in colorectal cancer.
Purpose of the Study:
- To quantify tumor buds in invasive breast cancer.
- To correlate tumor budding with histopathological features and clinical data.
Main Methods:
- Retrospective analysis of 50 invasive breast cancer cases (2012-2015).
- Tumor buds counted per 10 High Power Fields (HPFs) in H&E stained sections.
- Statistical analysis included frequencies, Chi-Square Test, and Crosstabs.
Main Results:
- Invasive ductal carcinoma was the predominant type (92%).
- High tumor budding (>20/10HPFs) was observed in 30 cases.
- Significant associations found between high tumor budding and lympho-vascular invasion, lymph node metastasis, advanced tumor staging, necrosis, and Monckeberg medial sclerosis.
Conclusions:
- Tumor budding shows potential as a new reporting parameter in breast cancer.
- It is a valuable indicator for assessing invasive breast cancer aggressiveness.
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