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Candida bloodstream infection in patients with systemic autoimmune diseases

M P Vaquero-Herrero¹, S Ragozzino¹, X Iriart²

¹Department of Internal Medicine, University Hospital of Salamanca-IBSAL, Salamanca, Spain.

Medecine Et Maladies Infectieuses

|March 2, 2020

Abstract

Objectives:

To describe the epidemiological, clinical and microbiological characteristics and mortality of patients with Candida bloodstream infection and systemic autoimmune diseases.

Methods:

We performed a retrospective multicenter study of candidemia in adults with systemic autoimmune diseases between 2010 and 2016.

Results:

Among 1040 patients with candidemia, 36 (3.5%) had a systemic autoimmune disease. The most common systemic autoimmune disease was rheumatoid arthritis (27.8%). The most common species was Candida albicans (66.7%). Twenty-two (61.1%) patients received a corticosteroid therapy and nine (25%) received an immunosuppressive therapy at the time of candidemia. The mortality rate was 27.8%.

Conclusions:

Systemic autoimmune diseases are not common in patients with candidemia. The unadjusted mortality rate was comparable to other candidemia studies in the general population.

Keywords:

Candidemia Corticosteroid therapy Immunosuppressive therapy Systemic autoimmune disease

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