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Related Concept Videos

Depression: Overview01:18

Depression: Overview

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: Dec 27, 2025

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
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Correction: Functionality of Top-Rated Mobile Apps for Depression: Systematic Search and Evaluation.

Chengcheng Qu1, Corina Sas1, Claudia Daudén Roquet1

  • 1School of Computing and Communications, Lancaster University, Lancaster, United Kingdom.

JMIR Mental Health
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Summary

This study corrects a previous article DOI. The corrected DOI is 10.2196/15321, ensuring accurate citation and retrieval of scientific research.

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Area of Science:

  • Bibliometrics
  • Scholarly Communication

Context:

  • Accurate citation is crucial for scientific integrity.
  • Digital Object Identifiers (DOIs) are essential for locating research.

Purpose:

  • To correct an erroneous DOI in a previously published article.
  • To ensure proper attribution and accessibility of scientific work.

Summary:

  • The article DOI has been corrected to 10.2196/15321.
  • This correction rectifies a citation error, improving the reliability of the scientific record.

Impact:

  • Facilitates accurate retrieval of the corrected article.
  • Enhances the integrity of scholarly communication and citation practices.