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Updated: Dec 26, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
Novel Quantitative PET Imaging Techniques in Tuberculosis.
Viplav Deogaonkar1, Bangkim Chandra Khangembam2, Siavash Mehdizadeh Seraj1
1Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA.
Fluorodeoxyglucose (FDG)-PET/CT imaging is increasingly vital for detecting tuberculosis (TB), assessing its extent, and monitoring treatment. A new quantification method offers robust parameters to measure the total disease burden in TB patients.
Area of Science:
- Nuclear Medicine
- Radiology
- Infectious Diseases
Background:
- Tuberculosis (TB) remains a significant global health challenge.
- Accurate assessment of disease burden and treatment response is crucial for effective TB management.
- Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography (FDG-PET/CT) has emerged as a valuable tool in evaluating various diseases.
Purpose of the Study:
- To review the current applications of FDG-PET/CT in tuberculosis.
- To introduce a novel quantification method for FDG-PET/CT in TB patients.
- To establish robust parameters for assessing total TB disease burden.
Main Methods:
- Comprehensive literature review on FDG-PET/CT in TB.
- Development and validation of a new quantification technique for FDG-PET/CT imaging in TB.
- Analysis of imaging parameters reflecting overall disease burden.
Main Results:
- FDG-PET/CT plays an expanding role in TB detection, staging, and treatment monitoring.
- The newly introduced quantification method provides reliable parameters for disease burden assessment.
- These parameters offer a more comprehensive understanding of the total impact of TB.
Conclusions:
- FDG-PET/CT is a versatile imaging modality for managing tuberculosis.
- The novel quantification approach enhances the utility of FDG-PET/CT for TB assessment.
- This method aids in a more precise evaluation of TB disease burden and treatment efficacy.
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