Visual Field Cluster Map Corresponding to Bruch Membrane Opening-minimum Rim Area Sectors in Open-angle Glaucoma

Area of Science:

• Ophthalmology
• Glaucoma Research
• Medical Imaging

Background:

• Open-angle glaucoma (OAG) is a leading cause of irreversible blindness.
• Understanding the structure-function relationship between the optic nerve head and visual field (VF) is crucial for OAG diagnosis and management.
• Bruch membrane opening-minimum rim area (BMO-MRA) is a key structural parameter of the optic nerve head.

Purpose of the Study:

• To investigate the structure-function relationship between BMO-MRA and VF in patients with OAG.
• To develop a novel VF cluster map based on BMO-MRA sectors.

Main Methods:

• Retrospective review of 67 eyes from 50 OAG patients.
• Spectral-domain optical coherence tomography (SD-OCT) for BMO-MRA measurement.
• Humphrey VF testing and correlation analysis between BMO-MRA sectors and VF points.

Main Results:

• A significant correlation was found between 43 out of 52 VF points and at least one BMO-MRA sector.
• A new VF cluster map was generated, illustrating these correlations.
• Distinct topographical relationships were observed between superior and inferior hemifield VF clusters and BMO-MRA sectors.

Conclusions:

• The novel VF cluster map demonstrates a significant structure-function relationship in OAG.
• This map can potentially enhance the diagnostic accuracy and evaluation of glaucoma progression.