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Related Concept Videos

Selectins01:25

Selectins

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Cells of the Innate Immune Response01:28

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
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Integrins01:10

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Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
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Adherens Junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Updated: Dec 26, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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Collectins: Innate Immune Pattern Recognition Molecules.

Valarmathy Murugaiah1, Anthony G Tsolaki1, Uday Kishore2

  • 1College of Health and Life Sciences, Brunel University London, London, UB8 3PH, UK.

Advances in Experimental Medicine and Biology
|March 11, 2020
PubMed
Summary
This summary is machine-generated.

Collectins are key innate immune molecules that recognize pathogens. They link innate and adaptive immunity by initiating pathogen clearance and modulating immune cell responses.

Keywords:
CollectinsInnate immunityPathogensPhagocytesReceptors

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Area of Science:

  • Immunology
  • Molecular Biology
  • Biochemistry

Background:

  • Collectins are collagen-containing C-type lectins crucial for innate immunity.
  • They possess a distinct structure: collagenous region, neck region, and carbohydrate recognition domain (CRD).
  • Collectins are found in serum and mucosal tissues, playing roles in pathogen recognition.

Purpose of the Study:

  • To describe the structure-function relationships of collectins.
  • To elucidate the diverse functions of collectins in immunity.
  • To detail collectin interactions with various pathogens.

Main Methods:

  • Structural analysis of collectin oligomerization.
  • Functional assays for pathogen recognition and immune response modulation.
  • Electron microscopy for visualizing collectin structures.

Main Results:

  • Collectins exhibit complex multimeric structures.
  • Collectins activate complement and mediate pathogen clearance via opsonization and phagocytosis.
  • Collectins bridge innate and adaptive immunity by interacting with antigen-presenting cells.

Conclusions:

  • Collectins are versatile innate immune molecules with diverse pathogen recognition capabilities.
  • Their structure dictates their function in pathogen clearance and immune response modulation.
  • Collectins are essential links between innate and adaptive immunity, crucial for host defense.