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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
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Siglecs at the Host-Pathogen Interface.

Yung-Chi Chang1, Victor Nizet2

  • 1Graduate Institute of Microbiology, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Rd., Taipei, 10051, Taiwan. yungchiychang@ntu.edu.tw.

Advances in Experimental Medicine and Biology
|March 11, 2020
PubMed
Summary
This summary is machine-generated.

Siglecs are receptors that bind sialic acid (Sia) and play a dual role in immunity. Some Siglecs are inhibitory, aiding pathogen evasion, while Siglec-1 promotes pathogen clearance and immune responses.

Keywords:
Pattern-recognition receptorSialic acidStreptococcusTrans-infection

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Area of Science:

  • Immunology
  • Microbiology
  • Glycobiology

Background:

  • Siglecs (sialic acid-binding immunoglobulin-like lectins) are key regulators of leukocyte function.
  • Pathogens exploit Siglec interactions for immune evasion, while some Siglecs mediate pathogen clearance.

Purpose of the Study:

  • To summarize the role of Siglecs at the host-pathogen interface.
  • To highlight Siglecs as potential targets for anti-infective strategies.

Main Methods:

  • Review of current literature on Siglec function in host-pathogen interactions.
  • Analysis of Siglec engagement by various pathogens (bacteria, viruses, parasites).

Main Results:

  • CD33-related Siglecs act as inhibitory receptors, often exploited by pathogens via sialic acid mimicry.
  • Siglec-1 functions as a phagocytic receptor, promoting bacterial clearance and antigen presentation.
  • Siglec-1 also facilitates entry of certain viruses and parasites into immune cells.

Conclusions:

  • Siglecs exhibit complex, context-dependent roles in modulating immune responses to infection.
  • Understanding Siglec-host-pathogen interactions is crucial for developing novel immune-based anti-infective therapies.