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ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways

Tuangtong Vongpipatana1, Taisuke Nakahama2, Toshiharu Shibuya1

  • 1Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Suita 565-0871, Osaka, Japan.

Journal of Immunology (Baltimore, Md. : 1950)
|March 15, 2020
PubMed
Summary

Adenosine deaminase acting on RNA 1 (ADAR1) is crucial for early thymocyte development. Its RNA-editing-dependent and -independent functions work together to prevent apoptosis and ensure proper T cell development.

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