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PTH and cardiovascular risk.

Damien Gruson1

  • 1Department of Clinical Biochemistry, cliniques universitaires Saint-Luc, université catholique de Louvain, Brussels, Belgium; Pôle de recherche en endocrinologie, diabète et nutrition, institut de recherche expérimentale et clinique, cliniques universitaires Saint-Luc, université catholique de Louvain, Brussels, Belgium.

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PubMed
Summary
This summary is machine-generated.

Parathyroid hormone (PTH) is linked to cardiovascular diseases, potentially causing heart damage and dysfunction. Measuring PTH may improve diagnosis and treatment selection for high-risk patients.

Keywords:
Cardiovascular riskPTHRisque cardiovasculaire

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Area of Science:

  • Endocrinology
  • Cardiology
  • Biomarker Research

Background:

  • Cardiovascular diseases (CVDs) are a leading cause of death and healthcare costs.
  • Biomarkers are crucial for diagnosing and managing CVDs.
  • Parathyroid hormone (PTH) regulates calcium and bone metabolism and is implicated in cardio-renal disorders.

Purpose of the Study:

  • To explore the role of parathyroid hormone (PTH) as a biomarker in cardiovascular diseases.
  • To investigate the detrimental effects of elevated PTH on cardiac cells and function.

Main Methods:

  • Review of existing literature on PTH and cardiovascular health.
  • Analysis of the molecular mechanisms linking PTH to cardiac pathology.

Main Results:

  • Elevated PTH levels are associated with cardiac hypertrophy, remodeling, and arrhythmias.
  • High PTH contributes to mitochondrial dysfunction, oxidative stress, inflammation, and cardiomyocyte necrosis.
  • Interactions between PTH, FGF23, and aldosterone negatively impact the cardiovascular system and endothelial function.

Conclusions:

  • PTH measurement may offer added value to existing cardiac biomarkers for patient sub-phenotyping.
  • Assessing PTH levels could aid in treatment selection for individuals at high cardiovascular risk.