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Updated: Dec 25, 2025

Gold Nanoparticle Synthesis

Gold Nanoparticle Synthesis

Published on: July 10, 2021

Gold Nanorod Synthesis with Small Thiolated Molecules.

Katherinne I Requejo¹, Anton V Liopo¹, Eugene R Zubarev¹

¹Department of Chemistry, Rice University, 6100 S Main Street, Houston, Texas 77005, United States.

Langmuir : the ACS Journal of Surfaces and Colloids

|March 29, 2020

Summary

New methods for synthesizing gold nanorods (AuNRs) using bioadditives like glutathione improve control over size and shape. These protocols offer reproducible synthesis of high-quality AuNRs for biomedical applications.

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Area of Science:

Nanotechnology
Materials Science
Biomedical Engineering

Background:

Gold nanorods (AuNRs) exhibit tunable size and shape, crucial for various applications.
Existing synthesis protocols often lack reproducibility and high yield, limiting biomedical use.
Developing reliable methods for small, high-quality AuNRs is essential.

Purpose of the Study:

To develop novel seed-mediated and seedless protocols for gold nanorod synthesis.
To investigate the effect of bioadditives (GSH, GSSG, l-cys, l-met) on AuNR aspect ratio and quality.
To achieve reproducible synthesis of AuNRs with controlled dimensions and high yield.

Main Methods:

Incorporation of bioadditives (glutathione, oxidized glutathione, l-cysteine, l-methionine) during AuNR growth.

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Last Updated: Dec 25, 2025

Gold Nanoparticle Synthesis

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Published on: July 10, 2021

Hydroquinone Based Synthesis of Gold Nanorods

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Published on: August 10, 2016

A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions

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Published on: February 5, 2016

Utilizing nanomolar and micromolar concentrations of bioadditives.

Comparison of seeded and seedless synthesis approaches.

Main Results:

Bioadditives reproducibly modified the aspect ratio of AuNRs in both seeded and seedless methods.
Smaller aspect ratios were generally achieved, with variations in length and width.
Seedless synthesis with GSH and GSSG yielded high-quality small nanorods, outperforming controls.

Conclusions:

Novel bioadditive-assisted protocols enable reproducible synthesis of gold nanorods.
The choice of bioadditive and synthesis method influences AuNR dimensions and quality.
These findings provide pathways for producing AuNRs suitable for biomedical applications.