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Updated: Dec 25, 2025

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes
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Nickel-Catalyzed Intramolecular Desulfitative C-N Coupling: A Synthesis of Aromatic Amines
Jiangjun Liu1, Xiuwen Jia1, Xuemeng Chen1
1Department of Dermatology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China.
Abstract:
A nickel-catalyzed intramolecular C-N coupling reaction via SO2 extrusion is presented. The use of a catalytic amount of BPh3 allows the transformation to take place under much milder conditions (60 °C) than previously reported C-N coupling reactions by CO or CO2 extrusion (160-180 °C). In addition, this method displays good functional group tolerance and versatility, as it can be applied to the synthesis of dialkyl aryl amines, alkyl diaryl amines, and triaryl amines. The robustness of the desulfitative C-N coupling is demonstrated by three high-yielding gram-scale reactions.
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