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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Updated: Dec 24, 2025

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
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Fibronectin in the Tumor Microenvironment.

Peter Qiao1, Zheng-Rong Lu2

  • 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

Advances in Experimental Medicine and Biology
|April 9, 2020
PubMed
Summary
This summary is machine-generated.

Fibronectin (FN) is a crucial glycoprotein in cancer. This review details its roles in tumor growth, spread, and treatment resistance, highlighting its potential in cancer imaging and future research directions.

Keywords:
CancerEpithelial-to-mesenchymal transitionExtracellular matrixExtradomain A fibronectinExtradomain B fibronectinFibroblastsFibronectinImagingIntegrinMetastasisPrognosisSplice variantsTumor microenvironmentWound healing

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Fibronectin (FN) is a large glycoprotein with diverse biological functions.
  • FN and its splice variants are implicated in various aspects of cancer biology.

Purpose of the Study:

  • To review the structural biology, functions, and molecular roles of FN in cancer.
  • To explore the potential of FN in cancer imaging.
  • To discuss future research directions for FN in the tumor microenvironment.

Main Methods:

  • Literature review and synthesis of existing research on fibronectin.
  • Analysis of fibronectin's role in cancer cell proliferation, metastasis, and chemoresistance.
  • Examination of fibronectin's application in cancer imaging techniques.

Main Results:

  • Fibronectin plays multifaceted roles in cancer progression, including proliferation, metastasis, and chemoresistance.
  • Specific splice variants of fibronectin contribute to distinct cancer-related functions.
  • Fibronectin shows promise as a target for cancer imaging.

Conclusions:

  • Fibronectin is a key player in tumor biology and the tumor microenvironment.
  • Targeting fibronectin and its variants may offer therapeutic strategies.
  • Further research into fibronectin's role in cancer imaging and therapy is warranted.