Related Experiment Video

Updated: Dec 24, 2025

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
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SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

Published on: November 1, 2019

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Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer

Pierre Gâtel1, Marc Piechaczyk1, Guillaume Bossis2

  • 1Equipe Labellisée Ligue Contre le Cancer, IGMM, Univ Montpellier, CNRS, Montpellier, France.

Advances in Experimental Medicine and Biology
|April 11, 2020
PubMed

Insights

Ubiquitin-like modifiers (UbLs) regulate protein function and are crucial in cancer. Targeting UbL pathways offers promising new strategies for cancer therapy development.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Ubiquitin-like (UbL) proteins are posttranslational modifiers regulating protein function and fate.
  • Dysregulation of UbL pathways is implicated in various pathologies, notably cancer.
  • Ubiquitin, SUMO, and Nedd8 are key UbLs involved in oncogenic and tumor suppressor pathways.

Purpose of the Study:

  • To review the roles and dysregulations of Ubiquitin, SUMO, and Nedd8 pathways in tumorigenesis.
  • To highlight recent advances in small molecules targeting UbL conjugating machineries for cancer therapy.

Main Methods:

  • Literature review of UbL pathways in cancer.
  • Analysis of dysregulation mechanisms in tumorigenesis.
  • Survey of small molecule inhibitors targeting UbL conjugation enzymes.

Main Results:

  • UbL pathways critically influence protein activity and stability in cancer.
  • Aberrant UbL conjugation/deconjugation enzymes contribute to cancer development and therapy resistance.
  • Targeting UbL conjugating enzymes shows therapeutic potential.

Conclusions:

  • The UbL system is a significant target for novel anticancer strategies.
  • Small molecules targeting UbL conjugating machineries represent a promising avenue for cancer treatment.
Keywords:
CancerNedd8SUMOUbiquitin

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